Table of Contents:
Dedication
Mitophagy and Biogenesis
Dedication
Autophagy and Cancer
Some Thoughts on Autophagy and Immunity
Autophagy: Friend or Foe?
Autophagy: If and When
What Happened When Autophagy Didn’t
Sugar Isn’t Always Sweet
Mitochondrial Mysteries
The Autophagy Process
Foreword
Foreword
Preface
Autophagy: Volume 1 – Contributions
Autophagy: Volume 2 – Contributions
Autophagy: Volume 3 – Contributions
Autophagy: Volume 4 – Contributions
Autophagy: Volume 5 – Contributions
Autophagy: Volume 6 – Contributions
Autophagy: Volume 7 – Contributions
Chapter 1. Overview of Autophagy
Abstract
Introduction
Specific Functions of Autophagy (A Summary)
Autophagy in Normal Mammalian Cells
Endoplasmic Reticulum
Endoplasmic Reticulum Stress
Major Types of Autophagies
Autophagosome Formation
Autophagic Lysosome Reformation
Protein Synthesis
Abnormal Proteins
Molecular Chaperones
The Endoplasmic Reticulum
Autophagic Proteins
Aggrephagy
Aggresome, Ubiquitin Proteasome, and Autophagic Systems
Monitoring Autophagy
Reactive Oxygen Species (ROS)
Mammalian Target of Rapamycin (mTOR)
Role of Autophagy in Tumorigenesis and Cancer
Role of Autophagy in Immunity
Autophagy and Senescence
Role of Autophagy in Viral Defense and Replication
Role of Autophagy in Intracellular Bacterial Infection
Role of Autophagy in Heart Disease
Role of Autophagy in Neurodegenerative Diseases
Cross-Talk between Autophagy and Apoptosis
Autophagy and Ubiquitination
Autophagy and Necroptosis
Mitochondrial Fusion and Fission
Selective Autophagy
References
Part I: Molecular Mechanisms
Chapter 2. Role of the Beclin 1 Network in the Cross-Regulation Between Autophagy and Apoptosis
Abstract
Introduction
Beclin 1 Structure in Autophagy
Transcriptional Regulation of Beclin 1 in Autophagy
Posttranslational Modification of Beclin 1 in Autophagy
Beclin 1-PI3KC3 Core Complex in Autophagy
Beclin 1-BCL-2 Complex in Autophagy
Beclin 1-Binding Proteins in Autophagy
Beclin 1-Mediated Interplay Between Apoptosis and Autophagy
Conclusions
Acknowledgments
References
Chapter 3. Role of Sirt1 as a Regulator of Autophagy
Abstract
Introduction
Characteristics of Sirt1
Autophagy
Regulation of Autophagy
Role of Sirt1 as a Regulator of Autophagy
Concluding Remarks
Acknowledgments
References
Chapter 4. Apoptosis Blocks Beclin 1-Dependent Autophagosome Synthesis
Abstract
Introduction
Apoptosis Inhibits Autophagosome Biogenesis via Dual-Functional Proteins
Apoptosis Inhibition of Autophagosome Formation by Protease Activity
Discussion
Acknowledgments
References
Chapter 5. Is Selective Autophagy Distinct from Starvation-Induced Autophagy?
Abstract
Introduction
Overview of Autophagy
Selective Autophagy
Autophagy and Disease
Conclusions
Acknowledgments
References
Part II: Role in Cell Death and Disease
Chapter 6. Molecular Mechanisms Underlying Cell Death Caused by Cationic Polymers
Abstract
Introduction
Characteristics of Cationic Polymers
Brief Overview of Molecular Mechanisms of Cell Death
Molecular Mechanisms of Cell Death Caused by Cationic Polymers
Conclusions
Acknowledgments
References
Chapter 7. The Role of Autophagy in Cell Death
Abstract
Introduction
Cell Death Subroutines
Autophagy and Apoptosis
Autophagy and Programmed Necrosis
Autophagy and ACD
Autophagy: A Complex Dynamical System
Conclusions
References
Chapter 8. The Role of Autophagy and Mitophagy in Mitochondrial Diseases
Abstract
Introduction
Mitochondrial Diseases
Autophagy
Mitophagy
Mitophagy in Mitochondrial Diseases
Conclusions
References
Chapter 9. Autophagy Regulation by HMGB1 in Disease
Abstract
Introduction
Nuclear HMGB1-Mediated Autophagy
Cytosolic HMGB1-Mediated Autophagy
Extracellular HMGB1-Mediated Autophagy
Transcriptional Regulation of HMGB1 in Autophagy
Posttranslational Modification of HMGB1 in Autophagy
HMGB1-Mediated Autophagy in Cancer Therapy
HMGB1-Mediated Autophagy in Inflammation
HMGB1-Mediated Autophagy in Immunity
HMGB1-Mediated Autophagy in the Central Nervous System
Conclusions
Acknowledgments
References
Chapter 10. Autophagy Defects and Lafora Disease
Abstract
Introduction
Pathomechanisms of Lafora Disease
Conclusions
References
Chapter 11. Regulation of Autophagy in Parkinson’s Disease: Insights into New Therapeutic Targets
Abstract
Introduction
Autophagy in PD
Autophagy as a Therapeutic Strategy
Concluding Remarks
Acknowledgments
References
Part III: Role in Cancer
Chapter 12. Role of Autophagy in Cancer Development via Mitochondrial Reactive Oxygen Species
Abstract
Introduction
Mitochondria and mitoROS
Relationship Between mitoROS and Autophagy
mitoROS-Regulated Autophagic Pathway in Cancer
Antitumor Drugs Targeting mitoROS-Related Autophagy
Conclusions and Perspectives
References
Chapter 13. Role of Autophagy in Cancer Therapy
Abstract
Introduction
Dual Role of Autophagy in Cancer
Therapy-Induced Stress and Autophagy
Autophagy and Tumor Immunity
Therapeutic Strategies Targeting Autophagy
Discussion
References
Chapter 14. The Role of Autophagy in Cancer and Chemotherapy
Abstract
Introduction
Pro- and Antitumor Functions of Autophagy in Tumorigenesis
The Dual Effect of Autophagy in Chemotherapy
Discussion
Acknowledgments
References
Chapter 15. Autophagy Activation in the Tumor Microenvironment: A Major Process in Shaping the Antitumor Immune Response
Abstract
Introduction
Hypoxia-Dependent Activation of Autophagy
EffectS of Hypoxia-Induced Autophagy on the Antitumor Immune Response
Autophagy Inhibition in Cancer Therapy: Friend or Foe?
Concluding Remarks
Acknowledgments
References
Chapter 16. Omega-3 DHA and EPA Conjugates Trigger Autophagy Through PPARγ Activation in Human Breast Cancer Cells
Abstract
Introduction
DHA and EPA Conjugates Induced Autophagy: Regulation of Beclin-1
Autophagic Process Triggered by DHA and EPA Conjugates
PPARγ as Central Mediator in the Cross Talk Between Autophagy and Apoptosis
Discussion
References
Chapter 17. Pro-oxidative Phytoagents Induce Autophagy in Tumors: Villain or Benefactor in Cancer Treatment?
Abstract
Introduction
Autophagy in Cancer
Autophagy in Anticancer Activities of Pro-oxidative Phytoagents
Final Remarks
Acknowledgments
References
Abbreviations and Glossary
Index
