Human Virology

Viruses are the ultimate parasites: they infect cells and hijack their molecular machinery in order to survive, often destroying the host cell in the process. In so doing, they present a major challenge to human health and well-being, with the continual emergence of new viral strains placing huge demands on healthcare systems internationally. Human Virology is the perfect introduction to the subject for anyone who needs to understand how viruses impact on human health, and how they can be managed in a clinical context. It does not seek to turn its readers into virologists, but to provide them with enough knowledge of the nature of viruses and viral infections to serve as an essential foundation for anyone encountering viruses in a clinical or biomedical context. Capturing this complex and rapidly-evolving subject with remarkable clarity, Human Virology describes the general principles of viral biology - the properties of viruses, their replication and genetics - along with disease and resistance, before introducing the infections caused by key groups of viruses. It concludes with an overview of the management of viral disease, including diagnosis and immunization. Reflecting our latest understanding of the molecular basis of viral diseases, Human Virology is the ideal resource for all students of medicine, dentistry, and the biological and biomedical sciences, who need a clear and focused introduction to the subject. New to this edition Greater explanation of virology at the molecular level, supported by new figures. Increased coverage of viral replication. Many chapters introduced by new 'Fundamental Concepts' panels, including viral lifecycle boxes, and timelines to show significant landmarks following the discovery of a virus, to give an at-a-glance overview of the topic. Case studies throughout illustrate the clinical relevance of the subject. Leslie Collier , Emeritus Professor of Virology, University of London., John Oxford , Professor of Virology, St Bartholomew's and the Royal London Hospital School of Medicine and Dentistry., and Paul Kellam , Virus Genomics Team Leader, Sanger Institute, Cambridge. Review(s) from previous edition "Covers all the bases well, with no major topic omitted. The authors' style is very "student friendly" and, sometimes, almost conversational in tone. This makes the book very easy to read. Layout is also user friendly with good use of tables/graphs/pictures. Reminders at each chapter end and appendices are also useful. - Professor Kevin Kerr, Harrogate District Hospital. "It is very comprehensive and covers most viruses that we encounter in clinical practice. I like the way how the chapters are divided into different types of viruses, its properties and clinical aspects of diseases. Chapter 7 is particularly useful as it mentions virus interaction in the community. Epidemiology is still an aspect that many people take for granted, but I think its an important element in virology. " - Dr Norzeihan Jan Bappu, Foundation 1 Doctor. CONTENTS 1: Virology: How it all began 2: General properties of viruses 3: Viral replication and genetics 4: How viruses cause disease 5: Resistance to virus infections 6: Viruses and cancer in humans 7: Viruses and the community 8: Upper respiratory tract and eye infections due to adenoviruses, coronaviruses (including SARS CoV), and rhinoviruses 9: Childhood infections caused by paramyxoviruses 10: Orthomyxoviruses and influenza 11: Gastroenteritis viruses 12: Rubella: postnatal infections 13: Parvoviruses 14: Poxviruses 15: Papovaviruses 16: Poliomyelitis and other picornavirus infections 17: The herpesviruses: general properties 18: The alphaherpesviruses: herpes simplex and varicella-zoster 19: The betaherpesviruses: cytomegalovirus and human herpesviruses 6 and 7 20: The gammaherpesviruses: epstein-barr virus and kaposi's sarcoma-assocociated herpesvirus 21: Introduction to the hepatitis viruses 22: The blood-borne hepatitis viruses B and delta 23: The enteric hepatitis viruses A and E 24: The bloodborne hepatitis flaviviruses 25: Retroviruses and AIDS 26: Lyssavirus and rabies 27: Arthropod-borne viruses 28: Exotic and dangerous infections: filoviruses, arenaviruses and hantaviruses 29: Prions and the spongiform encephalopathies 30: Viral diseases of the central nervous system 31: Intrauterine and perinatal infections 32: Viral infections in patients with defective immunity 33: Respiratory Infections 34: Sexually transmitted viral infections 35: Resurgent and emergent viral infections 36: The laboratory diagnosis of viral infections 37: Control of viral diseases by immunization 38: Antiviral chemotherapy