Essential Immunology for Surgeons

There has been a huge increase in the knowledge and understanding of the immunological processes involved in surgical practice in recent years. Anaesthesiologists and intensive care physicians are increasingly recognising the significant derangements of immune function in the critically ill patient and the possible therapeutic approaches to manage such patients (including new approaches in transplantation rejections, novel vaccination strategies in cancer treatment, as well as a better understanding of the beneficial effects of standard chemotherapy). Written by recognised experts in their field from both the UK and the US, and extensively referenced for further reading, Essential Immunology for Surgeons provides a concise, up-to-date, and readable account of immunology in general and its translation into key areas of clinical practice. It provides the necessary foundation for a critical understanding of this essential and rapidly expanding area of biological science that underpins and explains the modern concepts of a range of diseases and conditions, encompassing autoimmunity, infection, trauma, cancer, nutrition, organ transplantation, and various forms of therapy. Previously published as Immunological Basis for Surgical Science and Practice, this fully-updated textbook is aimed predominantly at the surgical trainee, but will also be of value to undergraduate and postgraduate clinicians of any discipline who wish to have a better understanding and knowledge of the subject, as well as to researchers studying the various core topics discussed in the book. Provides the reader with a concise and up-to-date account of immunology in general and its translation into key areas of clinical practice Includes a glossary of key words and terms and extensive references for further reading Contains numerous black and white line drawings and an 8-page colour plate section Helpful preparation for exit examinations for surgical specialities and disciplines, including MRCS, FRCS, FRACS, and FRCSC Oleg Eremin, Lead Clinician for Breast Services, Director of Research and Development, United Lincolnshire Hospitals NHS Trust; Clinical Director, Trent Comprehensive Local Research Network, Nottingham University Hospitals NHS Trust; and Special Professor of Surgery, Nottingham University Hospitals NHS Trust, UK, and Herb Sewell, Professor of Immunology and Consultant, University of Nottingham and University of Nottingham Hospital Trust, UK Professor Oleg Eremin graduated from the University of Melbourne, Australia, in 1964, before training in surgery at the Royal Melbourne Hospital and in Papua New Guinea. He moved to the UK in 1972, becoming Research Assistant at the University of Cambridge, between 1974 and 1980, undertaking research into tumour immunology and anti-cancer defences. In 1981 he became Senior Lecturer at the University of Edinburgh and Honorary Consultant Surgeon at the Edinburgh Royal Infirmary, and from 1985 to 1998 he was Regius Professor of Surgery at University of Aberdeen, and Honorary Consultant Surgeon at Aberdeen Royal Infirmary, before taking up his current posts. Professor Eremin has over 200 publications in peer-reviewed journals, 25 chapters in books, and is the editor of four textbooks. His recent research interests include tumour cell resistance and proteomics, and immunotherapy in advanced cancer with dendritic cells and hTERT. Professor Herb Sewell studied at Birmingham University gaining BDS Hons1 in 1973. Following further studies and research in immunology, he gained an MSc in 1975 and PhD in 1978. He subsequently pursued professional training and accreditation in clinical immunology and qualified in Medicine (MB ChB in 1983). He was appointed Senior Lecturer/Honorary Consultant in Immunology at the University of Aberdeen 1985 and subsequently moved to the University of Nottingham as Professor and Honorary Consultant in Immunology in 1990. In 2002 he was appointed a Pro Vice Chancellor/Vice President of Research at the University of Nottingham (2002-2007). His research interests focus primarily on the immunology of allergic disease and in particular on immunomodulation of the allergic response by the biological properties of allergens and by molecularly engineered antibodies. He has published over 120 peer reviewed original papers and reviews. Contributors: Dr Mark Aloysius, Research Fellow, Department of Surgery, University of Nottingham, Queen's Medical Centre, Nottingham, UK Professor Alfred Ayala, Professor of Surgery (Research), Division of Surgical Research, Department of Surgery, Alpert School of Medicine at Brown University and Rhode Island Hospital, USA Professor Anirban Bannerjee, Professor of Surgery, Department of Surgery; Director, Trauma Research Centre, University of Colorado Denver, USA Dr Eleanor M. Bolton, Assistant Director of Research, Department of Surgery, Addenbrooke's Hospital, Cambridge, UK Professor J. Andrew Bradley, Professor of Surgery, University of Cambridge; Honorary Consultant Surgeon and Clinical Director of Transplantation, Addenbrooke's Hospital, Cambridge, UK Dr Winston P. Choi, Surgery/Trauma Research Fellow, Resident Physician, Department of Surgery, University of Colorado Denver, USA Professor Oleg Eremin, Director of Research and Development and Lead Clinician for Breast Services, Clinical Director, Trent CLRN, Research and Development Department, United Lincolnshire Hospitals NHS Trust, UK Dr John C. Eun, Surgery/Trauma Research Fellow, Resident Physician, Department of Surgery, University of Colorado Denver, USA Professor Manuel Garcia-Caballero, Professor of Surgery and Consultant Surgeon, Faculty of Medicine, University of Malaga, Malaga, Spain Dr Daithi Heffernan, Assistant Professor of Surgery, Division of Surgical Research, Department of Surgery, Alpert School of Medicine at Brown University and Rhode Island Hospital, USA Professor Steven D. Heys, Deputy Head, Division of Applied Medicine and Consultant Surgeon, University of Aberdeen, and Grampian NHS Trust, Aberdeen, Scotland Dr Xin Huang, Research Associate, Division of Surgical Research, Department of Surgery, Alpert School of Medicine at Brown University and Rhode Island Hospital, USA Dr Joanne L. Lomas-Neira, Instructor of Surgery (Research), Division of Surgical Research, Department of Surgery, Alpert School of Medicine at Brown University and Rhode Island Hospital, USA Professor Ernest Moore, Bruce M Rockwell Distinguished Chair of Trauma and Chief of Surgery, Denver Health Medical Centre; Professor and Vice Chairman, Department of Surgery, University of Colorado Denver, USA Dr Adrian Robins, Associate Professor/Reader in Immunology, School of Molecular Medical Sciences, Queen's Medical Centre, Nottingham, UK Professor Herb Sewell, Professor of Immunology, Nottingham University Hospitals Trust, UK Professor Christopher Silliman, Senior Independent Investigator, Research Department, Bonfils Blood Centre, Denver; Professor of Paediatrics and Surgery, University of Colorado Denver, USA Dr Rajan Thakkar, Division of Surgical Research, Department of Surgery, Alpert School of Medicine at Brown University and Rhode Island Hospital, USA Dr Paddy Tighe, Associate Professor in Immunology, School of Molecular Medical Sciences, Queen's Medical Centre, Nottingham, UK Dr Chandan Verma, Research Scientist, Department of Surgery, University of Nottingham, Queen's Medical Centre, UK Professor Klaus W. J. Wahle, Visiting Professor, Department of Immunology, University of Strathclyde, Glasgow, and Division of Applied Medicine, University of Aberdeen, Scotland Professor Leslie G. Walker, Emeritus Professor of Cancer Rehabilitation, Institute of Rehabilitation, University of Hull, UK Dr James H. Wood, Postdoctoral Research Fellow, Department of Paediatric Surgery, The Children's Hospital, Aurora, USA; Resident Physician, Department of Surgery, University of Colorado Denver, USA CONTENTS 1: Basic immunology 2: Trauma and tissue injury 3: Transplantation immunology 4: Cancer and the immune response 5: Sepsis and the immune response 6: Nutrition and immunity 7: Therapy and host defences 8: Autoimmune disease and inflammatory disorders 9: Principles of immunological assays and molecular technologies