Textbook of Biochemistry with Clinical Correlations

This book presents a clear and precise discussion of the biochemistry of eukaryotic cells, particularly those of mammalian tissues, relates biochemical events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of abnormal biochemical processes in human disease. The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to human diseases. CONTENTS PART I STRUCTURE OF MACROMOLECULES. Chapter 1 Eukaryotic Cell Structure (Thomas M. Devlin). Chapter 2 DNA and RNA: Composition and Structure (Stephen A. Woski and Francis J. Schmidt). Chapter 3 Proteins I: Composition and Structure (Richard M. Schultz). PART II TRANSMISSION OF INFORMATION Chapter 4 DNA Replication, Recombination, and Repair (Howard J. Edenberg). Chapter 5 RNA: Transcription and RNA Processing (Frank J. Schmidt and David R. Setzer). Chapter 6 Protein Synthesis: Translation and Posttranslational Modifications (Dohn Glitz). Chapter 7 Recombinant DNA and Biotechnology (Gerald Soslau). Chapter 8 Regulation of Gene Expression (Daniel L. Weeks and John E. Donelson). PART III FUNCTIONS OF PROTEINS. Chapter 9 Proteins II: Structure-Function Relationships in Protein Families (Richard M. Schultz). Chapter 10 Enzymes: Classification, Kinetics, and Control (Henry Weiner). Chapter 11 The Cytochromes P450 and Nitric Oxide Synthases (Linda J. Roman and Bettie Sue Siler Masters). Chapter 12 Biological Membranes: Structure, Receptors, and Solute Transport (Thomas M. Devlin). Chapter 13: Fundamentals of Signal Transduction (George R. Dubyak). PART IV METABOLIC PATHWAYS AND THEIR CONTROL. Chapter 14 Bioenergetics, Mitochondria, and Oxidative Metabolism (Diana S. Beattie). Chapter 15 Carbohydrate Metabolism I: Major Metabolic Pathways and Their Control (Robert A. Harris). Chapter 16 Carbohydrate Metabolism II: Special Pathways and Glycoconjugates (Nancy B Schwartz). Chapter 17 Lipid Metabolism I: Synthesis, Storage, and Utilization of Fatty Acids and Triacylglycerols (Martin D. Snider, J. Denis McGarry, and Richard W. Hanson). Chapter 18 Lipid Metabolism II: Pathways of Metabolism of Special Lipids (Robert H. Glew). Chapter 19 Amino Acid and Heme Metabolism (Marguerite W. Coomes). Chapter 20 Purine and Pyrimidine Nucleotide Metabolism (Joseph G. Cory and Ann H. Cory). Chapter 21 Metabolic Interrelationships (Robert A. Harris and David W. Crabb). Chapter 22 Biochemistry of Hormones (Thomas J. Schmidt). PART V PHYSIOLOGICAL PROCESSES Chapter 23 Molecular Cell Biology (Thomas E. Smith). Chapter 24 Cell Cycle, Programmed Cell Death and Cancer (Richard M. Schultz). Chapter 25 Digestion and Absorption of Basic Nutritional Constituents (Ulrich Hopfer). Chapter 26 Vitamins and Minerals: Requirements and Function (Stephen G. Chaney). Chapter 27 Macronutrients: Metabolic Effects and Health Implications (Stephen G. Chaney). Appendix: Review of Organic Chemistry (Carol N. Angstadt). Glossary (Francis Vella). Index.