Immunology at a Glance

Immunology at a Glance provides a user-friendly overview of the body’s defence mechanisms. Ideal from day one of a medical, biomedical or life science course, the text begins with a basic overview of both adaptive and innate immunity, before progressing to applied immunological concepts, which look at what happens when things go wrong, and how, in clinical medicine, each body system can be affected by immunity. Each double-page spread corresponds to a typical lecture and diagrammatically summarises core concepts in immunology, through accessible schematic diagrams on left-hand pages, with key points concisely summarised on the right-hand page. There are also self-assessment essay questions so you can test your knowledge. New for this 10th edition: Thoroughly updated and reorganised chapters offer greater clarity and easier understanding for those new to the subject New chapters on cytokine receptors and ‘Immunology in the Laboratory’ A completely re-written section on autoimmunity A brand new companion website featuring self-assessment questions and PowerPoint slides of images from the book, ideal for teaching and revision at www.ataglanceseries.com/immunology Immunology at a Glance is the ideal companion for anyone about to start a new course in immunology and will appeal to medical and biomedical science students. Perfect for exam preparation, it provides the concepts and frameworks you need to succeed in your exam. CONTENTS Preface  Acknowledgements  Note on the ninth edition  How to use this book  Further reading  Immunity 1 The scope of immunology  2 Innate and adaptive immune mechanisms  3 Recognition and receptors: the keys to immunity  4 Cells involved in immunity: the haemopoietic system Innate immunity 5 Receptors of the innate immune system  6 Complement  7 Acute inflammation  8 Phagocytic cells and the reticuloendothelial system  9 Phagocytosis  Adaptive immunity (i) The molecular basis 10 Evolution of recognition molecules: the immunoglobulin superfamily  11 The major histocompatibility complex  12 The T-cell receptor  13 Antibody diversification and synthesis  14 Antibody structure and function  (ii) The cellular basis 15 Lymphocytes  16 Primary lymphoid organs and lymphopoiesis  17 Secondary lymphoid organs and lymphocyte traffic  (iii) The adaptive immune response 18 Antigen processing and presentation  19 The antibody response  20 Antigen–antibody interaction and immune complexes  21 Cell-mediated immune responses  (iv) Regulation 22 Tolerance  23 Cell communication and cytokines 24 The cytokine network 25 Immunity, hormones and the brain  Potentially useful immunity 26 Antimicrobial immunity: a general scheme  27 Immunity to viruses  28 HIV and AIDS 29 Immunity to bacteria  30 Immunity to fungi and ectoparasites  31 Immunity to protozoa  32 Immunity to worms  Undesirable effects of immunity 33 Immunodeficiency 34 Harmful immunity: a general scheme  35 Allergy and anaphylaxis  36 Immune complexes, complement and disease  37 Chronic and cell-mediated inflammation  38 Autoimmune disease 39 Transplant rejection  Altered immunity 40 Immunosuppression  41 Immunostimulation and vaccination  Immunity in health and disease 42 Cancer immunology 43 Immunity and clinical medicine  44 Investigating immunity  45 Immunology in the laboratory 46 Out of the past:: evolution of immune mechanisms 47 Into the future: immunology in the age of genomics  Self-assessment Self-assessment questions  Answers  Appendices Appendix I: Comparative sizes and molecular weights  Appendix II: Landmarks in the history of immunology and some  unsolved problems  Appendix III: CD classification  Index