Human Herpesviruses

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein-Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments. - International team of editors and contributors drawn from world's leading centers of excellence - Covers basic science and virology, combined with in-depth clinical coverage - Comprehensive, definitive and encyclopedic coverage Contents Part I. Introduction; Part II. Basic Virology and Viral Gene Effects on Host Cell Functions; Part II. Basic Virology and Viral Gene Effects on Host Cell Functions; Part II. Basic Virology and Viral Gene Effects on Host Cell Functions; Part III. Pathogenesis, Clinical Disease, Host Response, and Epidemiology; Part III. Pathogenesis, Clinical Disease, Host Response, and Epidemiology; Part III. Pathogenesis, Clinical Disease, Host Response, and Epidemiology; Part III. HHV- 6a, 6b and 7 Ann Arvin and Richard Whitley; Part III. Pathogenesis, Clinical Disease, Host Response, and Epidemiology; Part IV. Non-Human Primate Herpesviruses Ann Arvin, Patrick Moore and Richard Whitley; Part V. Subversion of Adaptive Immunity Richard Whitley and Ann Arvin; Part VI. Antiviral Therapy Richard Whitley; Part VII. Vaccines and Immunotherapy Ann Arvin and Koichi Yamanishi; Part VIII. Herpes as Therapeutic Agents Richard Whitley and Bernard Roizman. Contributors Bernard Roizman, Andrew Davison, Fenyong Liu, Z. Hong Zhou, Edward Mocarski, Jr., Gabriella Campadelli-Fiume, Joel Baines, Philip Pellett, Laura Menotti, Thomas Kristie, Rozanne Sandri-Goldin, John Hay, William Ruyechan, Brunella Taddeo, David Bhella, Teresa Compton, Adam Feire, Mark Stinski, Jeffrey Meier, Elizabeth White, Deborah Spector, David Anders, Julie Kerry, Gregory Pari, William Britt, A. Louise McCormick, Lawrence S. Young, John R. Arrand, Paul G. Murray, Patrick S. Moore, Richard Longnecker, Frank Neipel, Bala Chandran, Lindsey Hutt-Fletcher, Paul Lieberman, Jianhong Hu, Rolf Renne, Shannon Kenney, David Lukac, Yan Yuan, Thomas Schultz, Yuan Chang, George Klein, lngemar Emberg, Robert Means, Sabine Lang, Jae Jung, Ann Arvin, Richard Whitley, David Kimberlin, Charles Prober, David Koelle, Kaustuv Banerjee, Barry Rouse, Anna Wald, Lawrence Corey, Jennifer Moffat, Chia-chi Ku, Leigh Zerboni, Marvin Sommer, Jeffrey Cohen, Allison Abendroth, Jane Seward, Aisha Jumaan, Michael Jarvis, Jay Nelson, Mark Wills, Andrew Carmichael, J. H. Sinclair, J. G. Patrick Sissons, Suresh Boppana, Karen Fowler, Lenore Peirera, Ekaterina Maidji, Susan Fisher, Yasuko Mori, Koichi Yamanishi, Kaszuhiro Kondo, Fu-Zhang Wang, Philip Pelle, Vincent Emery, Duncan Clark, Richard Ambinder, Ethel Cesarman, Denis Moss, Scott Burrows, Rajiv Khanna, Dimitrios Lagos, Chris Boshoff, Jeppe Friborg, Mads Melbye, Jeffrey Martin, Nancy Raab-Traub, Donald Ganem, Julia Hilliard, Ravi Mahalingam, Donald Gilden, Peter Barry, William Chang, Armin Ensser, Bernhard Fleckenstein, Blossom Damania, Jatin Vyas, Benjamin Gewurz, Hidde Ploegh, Lauren Hook, Harvey Friedman, John Gnann, Jr., Paul Griffiths, Michael Boeckh, Mark Prichard, Karen Biron, George Kemble, Richard Spaete, Anne Gersho, Thomas Heineman, Andrew Morgan, Thomas Evans, Mary Wloch, Ann M. Leen, Uluhan Sili, Catherine Bollard, Cliona Rooney, Frank Tufaro, James Markert