Traumatic Brain and Spinal Cord Injury

Traumatic Brain and Spinal Cord Injury comprehensively covers the medical and pathological issues related to neurotrauma and its often devastating consequences. Written by globally renowned experts in the field, both clinicians and researchers will find this book invaluable to update their knowledge. This volume is divided into two sections, one covering the brain, the other the spinal cord. Each section discusses the following topics: • The demographic in the developed and developing world where neurotrauma is witnessing a massive expansion • Major clinical issues including advanced semi-experimental monitoring techniques utilized by neurosurgeons and intensivists and the potential use of identifying markers of tissue injury • Overview of major pathophysiological changes • The development of animal models; successes and limitations • Past, current and future therapeutic strategies including rehabilitative opportunities. Presenting the most up-to-date clinical and experimental research in neurotrauma, this volume is essential reading for neurologists, neurosurgeons, intensive care physicians and rehabilitative physicians. Edited by: Cristina Morganti-Kossmann, National Trauma Research Institute, Monash University, Melbourne Edited by: Ramesh Raghupathi, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia Edited by: Andrew Maas, Department of Neurosurgery, University Hospital Antwerp CONTENTS Preface Part I. Traumatic Brain Injury: 1. Current evaluation of TBI epidemiology in an ageing society with improved preventative measures Peter L. Reilly 2. Neurotrauma: an emerging epidemic in low and middle income countries G. K. Prusty, G. Gururaj and K. K. Dey 3. Blast induced traumatic brain injury and posttraumatic stress disorder Ankit I. Mehta, Gerald A. Grant and Lawrence F. Marshall 4. Psychological effects of mild traumatic brain injury: their nature and treatment Jennie Ponsford 5. Developments of neuroimaging techniques to diagnose and visualize white matter damage Virginia F. J. Newcombe and David K. Menon 6. New advances in monitoring the injured brain metabolism David M. Benglis, Jr, Brett Trimble and A. Ross Bullock 7. Potential use and limitations of microdialysis for monitoring of neurochemical changes after TBI Lars Hillered and Per Enblad 8. Metabolic and therapeutic differences in pediatric and adult TBI: implications for clinical care and therapeutic hypothermia Michael J. Bell and Patrick M. Kochanek 9. Utility of biomarkers for diagnosis and prognosis of traumatic brain injury Kevin K. W. Wang, Linda Papa and Ronald L. Hayes 10. Animal models of mild and severe TBI: what have we learned in the past 30 years? Jenna M. Ziebell, Frances Corrigan and Robert Vink 11. Pediatric brain trauma: what do age-appropriate animal models teach us about the age-at-injury? Ramesh Raghupathi and Jimmy W. Huh 12. The complexity of traumatic axonal injury Kathryn E. Saatman 13. Cerebral inflammation after traumatic injury: regulation of secondary damage, repair or both? Bridgette D. Semple and M. Cristina Morganti-Kossmann 14. Controversial findings on the role of NMDA receptors in traumatic brain injury Esther Shohami and Anat Biegon 15. Plasticity and recovery of the injured brain Dorothy A. Kozlowski and Theresa A. Jones 16. Design and analysis of clinical trials in TBI Bob Roozenbeek and Andrew Maas 17. Future perspectives for the treatment of traumatic brain injury patients: decompressive craniectomy, hypothermia and erythropoietin Alastair D. Nichol, Jeffrey V. Rosenfeld and D. James Cooper Part II. Traumatic Spinal Injury: 18. Global epidemiology of traumatic spinal cord injury Julio C. Furlan and Charles H. Tator 19. Classification and surgical stabilization of the injured spine Ricky Rasschaert and Thomas Kossmann 20. Spinal cord injury: pathophysiology and prospect of decompressive surgical treatment Jefferson R. Wilson and Michael G. Fehlings 21. Modeling the injured spinal cord to match the human condition Jacqueline C. Bresnahan and Michael S. Beattie 22. Myelin inhibitors of neurite outgrowth in spinal cord injury Michael F. Azari and Steven Petratos 23. Controversies on the role of inflammation in the injured spinal cord John C. Gensel and Phillip G. Popovich 24. Cell transplantation for spinal cord injury Nataliya Romanyuk, Pavla Jendelová and Eva Syková 25. Combining transplant-based and pharmacologic interventions with behavioral training and exercise for recovery from chronic spinal cord injury Marion Murray, Laura Krisa and John Houle 26. Chances and limits of locomotor training after damage to the central nervous system Volker Dietz 27. Temperature management and therapeutic hypothermia for the treatment of spinal cord injury W. Dalton Dietrich 28. Spinal cord injury clinical trials 1990–2010 Wise Young Index.