Early Pregnancy

Updated in light of recent research findings on fertilization, implantation and early pregnancy, this new edition combines the expertise of a wide range of internationally renowned authors to produce an authoritative, multidisciplinary approach to the management of first-trimester complications. Several international guidelines and consensus statements have been released since publication of the first edition and this has stimulated new focussed research questions that are addressed. The book's key recommendations provide clinicians with the tools to improve the patient's experience of the management of first-trimester complications. By combining essential elements of scientific research and clinical care, Early Pregnancy continues to set a benchmark for evidence-based management and will be essential reading for obstetricians, gynaecologists, neonatologists, ultrasonographers, and nurses seeking an understanding of the reproductive science of early pregnancy.

    Makes key recommendations on evidence-based patient care to clinicians
    A comprehensive reference text for all trainees interested in early pregnancy
    The new edition contains updated research and findings on fertilization and implantation

Table of Contents

1. Endometrial development and gene expression Alejandro Rincón, María Ruíz-Alonso, Patricia Díaz-Gimeno, Felipe Vilella and Carlos Simón
2. Decidualization and recurrent miscarriage Nick Macklon and Jan J. Brosens
3. Hemochorial development Graham J. Burton and Eric R. M. Jauniaux
4. Implantation Kelly Pagidas and Errol R. Norwitz
5. Early placental development and its disorders Kathleen A. Pennington, Lindsey B. Beffa and Danny J. Schust
6. Meiosis and the embryo Tiffany Oliver
7. Environmental toxicants and reproduction Clara H. Jeong, Changqing Zhou and Jodi A. Flaws
8. Thyroid physiology and early pregnancy Eveline W. C. M. van Dam and Cornelius B. Lambalk
9. Müllerian duct development Maribel Acién and Pedro Acién
10. Candidate genes for pregnancy loss Evica Rajcan-Separovic
11. Antiphospholipid antibodies and reproduction Lisa R. Sammaritano
12. Defining recurrent pregnancy loss Astrid Marie Kolte, Mariëtte Goddijn and Mary D. Stephenson
13. Guidelines on the diagnosis and management of miscarriage Caroline E. Overton and Kate O'Brien
14. The value of early pregnancy units Roy G. Farquharson
15. Investigation of recurrent miscarriage Feroza Dawood, Roy G. Farquharson and Mary D. Stephenson
16. Designing and optimizing treatment trials for recurrent pregnancy loss Myrthe van Dijk, Madelon van Wely and Mariëtte Goddijn
17. Risk-factors for first trimester miscarriage Ruth Bender-Atik, Barbara E. Hepworth-Jones and Pat Doyle
18. Tubal ectopic pregnancy and pregnancy of unknown location Emma Kirk
19. Non-tubal ectopic pregnancy Dimitrios Mavrelos and Davor Jurkovic
20. Ultrasound to diagnose and predict early pregnancy outcome Cecilia Bottomley
21. Three-dimensional virtual reality in early pregnancy Melek Rousian, Niek Exalto, A. H. J. Koning and Eric A. P. Steegers
22. Molar pregnancy Jemma Johns and Eric R. M. Jauniaux
23. Role of miscarriage evaluation Shweta Bhatt and Mary D. Stephenson
24. Inherited thrombophilia and early pregnancy Thijs E. van Mens and Saskia Middeldorp
25. Immunotherapy and recurrent pregnancy loss Anita Kuriya and William M. Buckett
26. Progesterone use in early pregnancy Hoda Harb and Arri Coomarasamy
27. Vanishing twin syndrome and long term outcome Anja Pinborg
28. Obesity and early pregnancy Christina E. Boots and Kelle H. Moley
29. Chronic endometritis and reproduction Dana B. McQueen and Mary D. Stephenson
30. Miscarriage after in-vitro fertilization Jonathan D. Kort and Ruth Bunker Lathi
31. HLA associations and recurrent pregnancy loss Henriette Svarre Nielsen and Thomas Vauvert F. Hviid
32. Midtrimester pregnancy loss Kelly M. McNamee and Roy G. Farquharson.

Roy Farquharson, Liverpool Women's Hospital
Roy Farquharson is Consultant Gynaecologist in the Miscarriage Clinic at Liverpool Women's Hospital.

Mary Stephenson, University of Illinois College of Medicine, Chicago, IL
Mary Stephenson is Professor and Department Head at the University of Illinois College of Medicine, and Director for the University of Illinois Recurrent Pregnancy Loss Program.
Contributors

Alejandro Rincón, María Ruíz-Alonso, Patricia Díaz-Gimeno, Felipe Vilella, Carlos Simón, Nick Macklon, Jan J. Brosens, Graham J. Burton, Eric R. M. Jauniaux, Kelly Pagidas, Errol R. Norwitz, Kathleen A. Pennington, Lindsey B. Beffa, Danny J. Schust, Tiffany Oliver, Clara H. Jeong, Changqing Zhou, Jodi A. Flaws, Eveline W. C. M. van Dam, Cornelius B. Lambalk, Maribel Acién, Pedro Acién, Evica Rajcan-Separovic, Lisa R. Sammaritano, Astrid Marie Kolte, Mariëtte Goddijn, Mary D. Stephenson, Caroline E. Overton, Kate O'Brien, Roy G. Farquharson, Feroza Dawood, Myrthe van Dijk, Madelon van Wely, Ruth Bender-Atik, Barbara E. Hepworth-Jones, Pat Doyle, Emma Kirk, Dimitrios Mavrelos, Davor Jurkovic, Cecilia Bottomley, Melek Rousian, Niek Exalto, A. H. J. Koning, Eric A. P. Steegers, Jemma Johns, Shweta Bhatt, Thijs E. van Mens, Saskia Middeldorp, Anita Kuriya, William M. Buckett, Hoda Harb, Arri Coomarasamy, Anja Pinborg, Christina E. Boots, Kelle H. Moley, Dana B. McQueen, Jonathan D. Kort, Ruth Bunker Lathi, Henriette Svarre Nielsen, Thomas Vauvert F. Hviid, Kelly M. McNamee