Essential Guide to Blood Coagulation

Thrombotic and bleeding disorders affect at least 10 million people in the US alone. There has also been a great deal of concern over travel-related deep vein thrombosis and therefore much more interest and research into the field of blood clotting. This new and concise practical guide will cover all the essentials one needs to know when managing thrombotic and bleeding disorders. The field of haematology is undergoing major advances in thrombosis research, including significant additions to recommended treatment protocols. The Essential Guide to Coagulation will distil the most clinically, up-to-date and relevant material from the literature for all those working in the field. Faced with a bleeding patient, it may be difficult to discern whether blood loss is due to a local factor or secondary to an underlying haemostatic defect. There are a range of simple and specialized laboratory texts which can be performed to further define the cause of bleeding in a patient. Since the first edition there have been many developments in the field including many new anticoagulant drugs. These new classes of "direct thrombin inhibitors" slow the coagulation cascade by directly binding to thrombin, a clotting factor essential in the clotting process. If thrombin is blocked, clot formation is delayed. A key component of this guide will be the latest treatment strategies available for patients. Table of Contents List of contributors Preface Abbreviations PART 1: General hemostasis 1 Schematic presentation of the hemostatic system Nils Egberg 2 Proposals for sampling instructions Margareta Blombäck, Nils Egberg 3 Laboratory investigations Jovan P. Antovic, Liselotte Onelöv, Nils Egberg PART 2: Bleeding disorders 4 Hereditary bleeding disorders Margareta Holmström, Lars–Göran Lundberg 5 Critical bleeding Maria Bruzelius, Anna Ågren, Hans Johnsson 6 Investigation of increased bleeding tendency Margareta Holmström, Lars–Göran Lundberg PART 3: Thromboembolic disorders 7 Venous thrombosis and pulmonary embolism Anders Carlsson 8 Investigations of thromboembolic tendency Margareta Holmström 9 Heart disease Håkan Wallen, Rickard Linder 10 Antiplatelet drug therapy and reversal of its effects Håkan Wallen, Hans Johnsson, Bo–Michael Bellander 11 Stroke and transient ischemic attack (TIA) Nils Wahlgren, Mia von Euler 12 Peripheral artery surgery Jesper Swedenborg 13 New oral anticoagulants (NOACs): focus on currently approved oral factor Xa and thombin inhibitors Rickard E. Malmström, Hans Johnsson PART 4: Special hemostasis 14 Hemostasis in obstetrics and gynecology Katarina Bremme 15 Hemostatic defects in children Pia Petrini, Susanna Ranta 16 Emergency conditions associated with coagulation: DIC, HIT and TTP/HUS Jovan P. Antovic, Margareta Holmström