For more than 55 years, "Schiff" has been acclaimed as the most outstanding liver book in the world. This new 12th edition brings the field completely up to date and includes a companion website that features a wide-variety of accessory materials. The text is evidence-based to offer hepatologists and gastroenterologists treating patients with liver disease a comprehensive and essential resource. The text highlights clinical practice and covers anatomy, pathology, testing, imaging, and the effects of liver disease on other organs. The book is written in clear and accessible terms and key features include:
Treatment guidelines and management algorithms for every disease
Full-color attractive design throughout the text
Informative section overviews for each section
Concise key concepts box in every chapter
A full liver transplant section
This 12th edition is thoroughly revised with the latest clinical information. The new edition offers:
Information on acute and chronic liver failure and infections in cirrhosis
Over 100 MCQs
Downloads for Powerpoint™ making the content ideal for presentations
Schiff's Diseases of the Liver is designed to be a first-stop reference for dealing with today’s demanding clinical situations.
CONTENTS
Part I Overview: Clinical Fundamentals of Hepatology
1 History Taking and Physical Examination for the Patient with Liver Disease, 3
Esperance A. Schaefer and Lawrence S. Friedman
2 Laboratory Tests, Noninvasive Markers of Fibrosis, Liver Biopsy, and Laparoscopy, 17
Michael P. Curry and Lennox J. Jeffers
3 Noninvasive and Invasive Imaging of the Liver and Biliary Tract, 38
Koushik K. Das, Matthew A.Morgan, and Gregory G. Ginsberg
Part II General Considerations
4 Physioanatomic Considerations, 73
Ian R. Wanless
5 Bilirubin Metabolism and Jaundice, 103
Allan W. Wolkoff and Paul D. Berk
6 Hepatic Histopathology, 135
Zachary D. Goodman
7 Mechanisms of Liver Injury, 200
Harmeet Malhi and Gregory J. Gores
8 Hepatic Manifestations of Systemic Disorders, 218
Stuart C. Gordon and Humberto C. Gonzalez
9 The Liver in Pregnancy, 244
Nancy Reau and Yannick Bacq
Part III Consequences of Liver Disease
10 Hepatic Fibrosis, 271
Scott L. Friedman
11 Preoperative Evaluation of the Patient with Liver Disease, 290
Patrick S. Kamath and Mark T. Keegan
12 Management of Portal Hypertension, 304
Guadalupe Garcia-Tsao and Juan G. Abraldes
13 Renal Complications of Liver Disease and the Hepatorenal Syndrome, 336
Xingxing S. Cheng and W. Ray Kim
14 Pulmonary Manifestations of Liver Disease, 353
Michael B. Fallon and Anil Seetharam
15 Ascites and Spontaneous Bacterial Peritonitis, 365
Vicente Arroyo and Javier Fern´andez
16 Hepatic Encephalopathy, 387
Chathur Acharya and Jasmohan S. Bajaj
17 Acute Liver Failure, 411
Robert J. Fontana and Khurram Bari
18 Acute-on-Chronic Liver Failure, 432
Florence Wong
19 Malnutrition and Liver Disease, 460
Craig McClain, Irina Kirpich, and Laura Smart
Part IV Cholestatic Disorders
20 Primary Sclerosing Cholangitis, 491
John M. Vierling
21 Primary Biliary Cholangitis, 523
Cynthia Levy, Andres F. Carrion, and Marlyn J. Mayo
22 Autoimmune Hepatitis, 546
Gideon M. Hirschfield and Gwilym J. Webb
Part V Viral Hepatitis
23 Hepatitis A and E, 565
Kenneth E. Sherman and Shyam Kottilil
24 Hepatitis B and D, 584
Marc G. Ghany and Naveen Gara
25 Hepatitis C, 628
Michael W. Fried, Jama M. Darling, and Stanley M. Lemon
Part VI Alcohol- and Drug-induced Liver Disease
26 Alcoholic Liver Disease, 701
Mack C. Mitchell and Gyongyi Szabo
27 Drug-induced Hepatotoxicity, 740
Dominique Larrey, Jose Ursic-Bedoya, and Lucy Meunier
28 Mechanisms of Drug-induced Liver Injury, 774
Paul B. Watkins and Merrie Mosedale
Part VII Genetic and Metabolic Disease
29 Wilson Disease, 801
Michael L. Schilsky and Aftab Ala
30 Hemochromatosis and Iron Storage Disorders, 820
Kris V. Kowdley and Priya Handa
31 Alpha-1 Antitrypsin Deficiency, 843
David H. Perlmutter
32 Nonalcoholic Fatty Liver Disease, 867
Curtis K. Argo, Zachary H. Henry, and Stephen H. Caldwell
Part VIII Vascular Diseases of the Liver
33 Vascular Liver Disease, 911
Dominique-Charles Valla
34 The Liver in Circulatory Failure, 935
Santiago J. Munoz, Hanisha R. Manickavasagan, and Idean Amirjazil
Part IX Benign and Malignant Tumors; Cystic Disorders
35 Benign Tumors, Nodules, and Cystic Diseases of the Liver, 949
Julien Calderaro and Jessica Zucman-Rossi
36 Hepatocellular Carcinoma, 977
Maddie Kubiliun and Jorge A. Marrero
37 Surgical Options in Liver Cancers, 989
Garrett R. Roll and John Paul Roberts
Part X Infectious and Granulomatous Disease
38 Amoebic and Pyogenic Liver Abscesses, 1005
Marco A. Olivera-Mart´ýnez and David Kershenobich
39 Parasitic Diseases, 1013
Michael A. Dunn
40 Granulomas of the Liver, 1028
James H. Lewis
Part XI Elements of Liver Transplantation
41 Selection of Candidates and Timing of Liver Transplantation, 1055
Meaghan Phipps, Alyson N. Fox, and Robert S. Brown Jr.
42 Immunosuppression: The Global Picture, 1065
Caroline C. Jadlowiec, Timucin Taner, and Russell H. Wiesner
43 The First Six Months Following Liver Transplantation, 1079
K. Rajender Reddy and Manuel Mendizabal
44 Long-term Management of the Liver Transplant Patient, 1093
Timothy M. McCashland
45 The Liver Transplant Procedure, 1107
Bijan Eghtesad, Koji Hashimoto, and John Fung
46 Recurrent Disease Following Liver Transplantation, 1127
Haripriya Maddur and Josh Levitsky
47 The Role of Retransplantation, 1143
Peter L. Abt and Kim M. Olthoff
48 Controversies in Liver Transplantation, 1156
James F. Trotter
Index, 1169
