The first book dedicated to this common, serious, and complex equine disease, Equine Laminitis is the gold-standard reference to the latest information on every aspect of the disease and its treatment.
* Provides the first book devoted specifically to equine laminitis * Discusses the current state of knowledge on all aspects of the disease, including its history, relevant anatomical considerations, pathophysiology, the diagnostic workup, and clinical treatment * Presents 50 chapters written by leading international experts, under the editorship of the foremost authority on equine laminitis * Offers a thorough understanding of this common affliction, grounded in the scientific literature * Describes effective prevention and treatment plans
CONTENTS
Contributors, vii Foreword, x Abbreviations, xii Part 1: Overview: From Basic Research to Caring for the Laminitis Patient 1 Historical Perspective on Equine Laminitis, 3 Donald M.Walsh and Teresa A. Burns 2 Laminitis: An Overview, 11 James K. Belknap 3 Anatomy and Function of the Equine Digit, 13 A.H. Parks 4 Lamellar Function at the Cellular Level, 22 Christopher C. Pollitt 5 Digital Biomechanics Relevant to Laminitis, 39 Jonathan Merritt, Helen Davies and Andrew H. Parks Part 2: Pathophysiology of Laminitis 6 Overview, 51 James K. Belknap 7 Experimental Models of Laminitis: Starch Overload, 54 Susan C. Eades 8 Experimental Models of Laminitis: Oligofructose Overload, 59 Christopher C. Pollitt and Gabriel J. Milinovich 9 Experimental Models of Laminitis: BlackWalnut Extract, 64 John F. Peroni 10 Experimental Models of Laminitis: Hyperinsulinemia, 68 Catherine McGowan and Janet Patterson-Kane 11 Hemodynamic Events in Laminitis, 75 John F. Peroni, Susan C. Eades and Simon R. Bailey 12 The Role of Thrombosis and Coagulation in Equine Laminitis, 82 Simon R. Bailey 13 Leukocytes and Inflammatory Signaling in Laminitis: Leukocytes, 91 Rafael R. Faleiros and James K. Belknap 14 Leukocytes and Inflammatory Signaling in Laminitis: Inflammatory Signaling, 102 Britta Leise 15 Role of Proteases in Laminitis, 115 Samuel J. Black, LeWang, Erica Pawlak, Fengqiu Zhang, John Loftus and Dominique Alfandari 16 Endocrine and Metabolic Dysregulation in Laminitis: Role of Pituitary Dysfunction, 134 Philip J. Johnson 17 Endocrine and Metabolic Dysregulation in Laminitis: Role of Corticosteroids, 141 Philip J. Johnson 18 Metabolic Syndrome in Humans and Horses: The Relationship Between Obesity and Insulin Resistance, 149 Teresa A. Burns and Ramiro E. Toribio 19 Dysregulation of the Lamellar Basal Epithelial Cell in Laminitis: Role of the Cytoskeleton and Cell Junctions, 167 Christopher C. Pollitt 20 Structural Dynamics of Displacement of the Distal Phalanx, 176 Andrew H. Parks Part 3: Clinical Presentation of Equine Laminitis 21 General Clinical Aspects of the Laminitis Case, 183 Andrew van Eps 22 Sepsis-Related Laminitis, 191 Susan C. Eades 23 Laminitis in Equine Metabolic Syndrome, 196 Andy E. Durham 24 Laminitis in Pituitary Pars Intermedia Dysfunction, 204 Philip J. Johnson 25 Supporting Limb Laminitis, 210 Gary M. Baxter Part 4: Diagnostic Evaluation of Equine Laminitis 26 Detailed Physical Examination for Laminitis, 217 Richard A. Mansmann and Hans H. Castelijns 27 Diagnostic Imaging, 226 Andrew H. Parks and James K. Belknap 28 The Digital Venogram, 240 Amy Rucker 29 Endocrine and Metabolic Evaluation in Horses with Laminitis, 252 Ramiro E. Toribio and Teresa A. Burns Part 5: Medical Treatment of the Laminitic Patient 30 General Supportive Care for the Laminitis Case, 269 Andrea E. Floyd and Debra R. Taylor 31 Common Therapies: Anti-Inflammatory Therapy, 277 Thomas J. Divers 32 Vasoactive Drug Therapy, 284 Simon R. Bailey and Susan C. Eades 33 Analgesia, 291 Bernd Driessen and Laura Zarucco 34 Digital Hypothermia, 306 Andrew W. van Eps and Christopher C. Pollitt 35 Equine Sepsis, 316 Samuel D. Hurcombe and Susan J. Holcombe 36 Equine Metabolic Syndrome, 329 Andy E. Durham 37 Pituitary Pars Intermedia Dysfunction, 334 Dianne McFarlane, Philip J. Johnson and Harold C. Schott, II Part 6: Treatment of Laminitis: Digital Support and Stabilization of the Distal Phalanx 38 Therapeutic Shoes: Application of Principles, 343 Stephen E. O Grady 39 Solear Support Techniques, 354 Raul J. Bras 40 Approaching Digital Management Prior to Displacement of the Distal Phalanx, 360 Randy B. Eggleston 41 Hoof Care Management of Horses with Displacement of the Distal Phalanx, 364 Andrew H. Parks Part 7: Treatment of the Laminitis Case 42 The Use of Casts in Equine Laminitis, 377 James K. Belknap and Raul J. Bras 43 Deep Digital Flexor Tenotomy, 382 R. Wayne Waguespack, Jr 44 Dorsal HoofWall Techniques, 391 Amy Rucker 45 Complications of Laminitis, 402 Robert J. Hunt and James K. Belknap Part 8: Management of Chronic Laminitis 46 Management Changes in the Laminitis Case, 413 Andrew Van Eps, Robert J. Hunt, James K. Belknap and Jeff Ridley Part 9: Prevention of Laminitis 47 Overview of Laminitis Prevention, 423 James K. Belknap and Andy E. Durham 48 Prevention of Supporting Limb Laminitis, 427 Harry J. Markwell and Gary M. Baxter 49 Prevention of Sepsis-Related Laminitis, 432 Samuel D. Hurcombe and Susan J. Holcombe 50 Nutritional Management for Avoidance of Pasture-Associated Laminitis, 436 Pat Harris Glossary, 442 Index, 445
