Inflammatory Bowel Disease

This book provides a detailed, comprehensive review of the basic science behind inflammatory bowel disease as well as evidence-based clinical guidance on diagnosis, treatment and long-term management. CONTENTS 1. Overview of Inflammatory Bowel Diseases: From Bench to Bedside and Back. 2. Heterogeneity of Inflammatory Bowel Diseases. 3. Epidemiology: The Changing Faces of Crohn's Disease and Ulcerative Colitis. 4. Genetics of Inflammatory Bowel Disease. 5. Experimental mouse models of Inflammatory Bowel Disease: new insights into pathogenic mechanisms. 6. The Normal Intestinal Mucosa - A State of 'Controlled' Inflammation. 7. Innate Immunity. 8. Adaptive Immunity (Novel Effector Cells/TGF SMAD). 9. The Bacterial/Epithelial/Lymphocyte Interface. 10. The Mucosal Inflammatory Response: Cytokines and Chemokines IL23 TH13 TL1A. 11. Role of the Microcirculation in Chronic Gut Inflammation. 12. Remission, Relapse, Intestinal Healing and Repair. 13. Antibodies underpinnings genetics, etc. 14. Pathophysiology of Inflammatory Bowel Disease: The Effect of Inflammation on Intestinal Function. 15. Pathogenesis: Systemic Consequences of Intestinal Inflammation?. 16. Explaining the Signs and Symptoms of Inflammatory Bowel Diseases. 17. Clinical Course and Complications of Ulcerative Colitis and Ulcerative Proctitis. 18. Clinical Features and Complications of Crohn's Disease. 19. Mechanisms of Extraintestinal Manifestations. 20. Pathology of Inflammatory Bowel Diseases: A Critical Appraisal in Diagnosis and Management. 21. An Endoscopist's Perspective of Diagnosis: When, Where and What to Do Add Capsule. 22. Radiologic/Radiographic Features of Ulcerative Colitis and Crohn's Disease Enteroscopy, MRI, ultrasound. 23. New Diagnostic Approaches- New chapters with serologics, integrating serologics, endoscopy and radiology and genomics. 24. Differential Diagnosis of Colitis. 25. Inflammatory Bowel Disease in the Era of Managed Care. 26. Pharmaco Economic Outcomes/ Disease Activity Indices/Study Design. 27. Quality of Life Issues and Disease Activity Indices. 28. Multi-Site Therapeutic Modalities for Inflammatory Bowel Diseases-Mechanisms of Action, Combination Therapy. 29. Single Site Therapeutics for Inflammatory Bowel Diseases. 30. Role of Antibiotics and Probiotics in the Management of Inflammatory Bowel Disease. 31. Nutrition and Inflammatory Bowel Diseases. 32. Medical Management of Ulcerative Colitis. 33. Surgical Management of Ulcerative Colitis. 34. Clinical Characteristics and Management of Pouchitis. 35. Specific Management of Crohn's Disease. 36. Surgical Treatment of Crohn's disease/Perianal Crohn's Disease37. Management of Post-operative Prevention of Recurrence in Crohn's Disease 38. The Molecular Pathology of IBD-Associated Neoplasia and Preneoplasia. 39. Dysplasia in Inflammatory Bowel Disease: Clinical Pathology and Current Surveillance Methods. 40. Hepatobiliary Diseases in Patients with Inflammatory Bowel Diseases. 41. Articular and Ocular Complications of Inflammatory Bowel Diseases. 42. Cutaneous Manifestations of Inflammatory Bowel Diseases. 43. Fertility and Pregnancy in Inflammatory Bowel Diseases. 44. Special Considerations in Pediatric Inflammatory Bowel Diseases. 45. Collagenous and Lymphocytic Colitis. 46. Microcirculation, Diversion, Diverticular and other non-infectious colitides. 47. Pseudomembranous Colitis and clostridium difficile colitis. 48. Infectious Colitis. 49. Human Immunodeficience Virus and Inflammatory Bowel Diseases. 50. Bone metabolism and inflammatory bowel disease. 51. Pharmaceutical industry, what do they need?. 52. Comprehensive approaches to patient risk. Risk v. Benefit in biologics, immune. 53. Complimentary medicine. 54. The Present and Future of Research and Treatment of Inflammatory Bowel Disease