The Textbook of Nanoneuroscience and Nanoneurosurgery

Nanoneuroscience, nanoneurosurgery, and nanobioelectronics have the potential to revolutionize medicine and improve the prevention, diagnosis, and treatment of neurological disorders over the next 10-20 years. The Textbook of Nanoneuroscience and Nanoneurosurgery presents a state-of-the-art review of the field, providing current information about nanoplatforms and their use in neurosurgery, neurology, neuroscience, and neuroradiology. The text also reviews the latest regulatory guidelines that influence the translation of nanotechnological research from the laboratory to the clinic, as well as the most recent information on biodevices and pharmaceutical spinoffs. It highlights presidential and congressional initiatives and programs that may significantly impact the field in the near future. Chapters discuss the latest science and technologies—which are applied to diagnosis and treatment of neurological disorders—as well as regulatory issues that impact product development. This volume describes advances that have already been translated to the clinic or hold significant promise for future application in nanoneurosurgery, as well as their potential impact. A full-color text, the book contains contributions by more than 120 researchers, original and descriptive illustrations, and more than 3,000 references. Offering broad coverage of nanotechnological applications in diverse areas and addressing FDA regulation and healthcare policy, this volume provides a foundation of ideas and methods for scientists and physicians to devise successful, less invasive procedures for future treatment of nervous system disorders. Features Presents state-of-the-art reviews, techniques, and methodologies in the field of nanoneurosurgery Discusses nanoplatforms and their use in neurosurgery, neurology, neuroscience, and neuroradiology Covers applications of nanotechnology in neurology, including neurodegenerative disorders, autoimmune disorders, neuro-oncology, neurorehabilitation, neurotrauma, and spinal disorders Describes current clinical trials and practices Addresses safety concerns, FDA regulations, and strategies to reduce toxicity Discusses the role of US Congressional policies and the impact of the BRAIN initiative by President Obama on nanoneuroscience and nanoneurosurgery Provides a full-color text with more than 3,000 references Babak Kateb, founding chairman of the board of SBMT and Brain Mapping Foundation, Scientific Director of SBMT, and President of Brain Mapping Foundation, West Hollywood, CA, USA, Director of the National Center for Nano-Bio-Electronics, NASA Research Park, Moffet, CA, USA, Senior Editor of SBMT-NeuroMapping & Therapeutics, Research Scientist, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA, and Visiting Scientist, NASA/Jet Propulsion Laboratory (JPL), Pasadena, CA, USA. John D. Heiss, chair of the Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, and Clinical Professor of Neurosurgery, George Washington University, Washington, DC, USA. Table of Contents Chapter 1: From Nanotechnology to Nanoneuroscience/Nanoneurosurgery and Nanobioelectronics: A Historical Review of Milestones Vicky Yamamoto, Giancarlo Suffredini, Shouleh Nikzad, Michael E. Hoenk, Miriam S. Boer, Charlie Teo, John D. Heiss, and Babak Kateb Chapter 2: Nanoneurology and Nanoneurosurgery Geoffrey S. F. Ling, Robbin Miranda, and Gill Pratt Chapter 3: Nanopolymers and Nanoconjugates for Central Nervous System Diagnostics and Therapies Giancarlo Suffredini and Lucien M. Levy Chapter 4: Micelles and Liposomes: Lipid Nanovehicles for Intracerebral Drug Delivery Massimo S. Fiandaca and Krystof S. Bankiewicz Chapter 5: Peptide and Protein-Based Nanoparticles Ayaz M. Khawaja and John D. Heiss Chapter 6: Endohedral Metallofullerenes, Iron Oxide Agents, and Gold Nanoparticles for Brain Imaging Martina A. McAteer and Robin P. Choudhury Chapter 7: Carbon Nanoplatforms and Their Application for Neurological Disorders Houman Badrzadeh, Peyman Tashkandi, Michelle Knosp, and Babak Kateb Chapter 8: Dendrimers Ayaz M. Khawaja and John D. Heiss Chapter 9: Ligand-Based Targeting of Therapeutic and Imaging Agents for Cancer Qimeng Quan, Seulki Lee, and Xiaoyuan Chen Chapter 10: Immune-Based Targeting in Cancer Dwain K. Irvin, Chirag G. Patil, and Keith L. Black Chapter 11: Directed Drug Convection Using Magnetic Nanoparticles as Therapeutic Carriers: Meeting the Challenge of Specific Brain Pharmacotherapeutics, Non-Ligand-Based Central Nervous System Targeting, Including Magnetic Focusing David F. Moore, Vinith Yathindranath, Torsten Hegmann, Donald Miller, Marc Pelletier, and Raphael Schiffmann Chapter 12: Intralesional and Intraparenchymal Convection-Enhanced Delivery of Nanoparticles Tatsuhiro Fujii, Daniel Angeles, Li-Chen Hsu, Rahul Jandial, and Mike Chen Chapter 13: Transport of Nanoparticles across Blood–Brain Barrier Robert T. Wicks, Zev A. Binder, and Alessandro Olivi Chapter 14: Nanomedicine Treatment Strategies That Exploit Unique Characteristics of Tumor Vasculature and Microenvironment Jun Wu, Tats Fujii, and Mike Y. Chen Chapter 15: Focused Ultrasound for Noninvasive Neuromodulation Martin O. Culjat, Richard E. Fan, Meghedi Babakhanian, Amit P. Mulgaonkar, Rahul S. Singh, Warren S. Grundfest, and William P. Melega Chapter 16: Nanosensors J. Matthew Dubach and Heather A. Clark Chapter 17: Implantable Infusion Pumps Incorporating Nanotechnology Ellis Meng, Tuan Hoang, and Uttam Sinha Chapter 18: Nanostructured Surfaces for Intracerebral Neurotransmitter Recording David A. Price, Artin Petrossians, Pooja M. Talauliker, Francois Pomerleau, Peter Huettl, Florian Mansfeld, James Weiland, J. Todd Hastings, and Greg A. Gerhardt Chapter 19: Therapy for Neuronopathic Lysosomal Storage Diseases Ayaz M. Khawaja, John D. Heiss, and Roscoe O. Brady Chapter 20: Nanotechnology for Cerebral Aneurysm Treatment Jean Paul Allain, Teodoro Tigno, and Rocco Armonda Chapter 21: Improving Treatment of Stroke through Nanotechnology Francesca Nicholls, Natalia Gorenkova, Ellen Bible, Christy Franco, David Chau, Christos Tolias, Kevin Shakesheff, Jennifer West, and Michel Modo Chapter 22: Molecular Medical Devices for Nanoneurosurgery Rutledge Ellis-Behnke Chapter 23: Applications of Nanotechnology in Epilepsy Paul R. Carney Chapter 24: Applications of Nanotechnology to Diseases of the Spine Bryn S. Moore and Steven A. Toms Chapter 25: Nanoparticle-Based Treatment and Imaging of Brain Tumors: Potentials and Limitations Bong-Seop Lee, Christopher J. Hanson, Rina Amatya, Esther Chung, Mansur Ghani, Allen Yen, Keith L. Black, and John S. Yu Chapter 26: Tumor-Targeted Nanodrugs for Treatment of Primary Brain Tumors Joseph Cheatle and Michele Aizenberg Chapter 27: Application of Nanotechnology in the Diagnosis and Treatment of Brain Metastasis Joel C. Sunshine, Zachary D. Guss, Jay J. Pillai, and Michael Lim Chapter 28: Nanotechnology in Extra-Axial and Pituitary Tumors Aimee Two, J. Peter Gruen, and Gabriel Zada Chapter 29: Using Nanoparticles in Diagnosis and Treatment of CNS Infection Zion Zibly, Cody D. Schlaff, and John D. Heiss Chapter 30: Applications of Nanotechnology in Movement Disorders Patrick Pezeshkian, Karlo J. Lizarraga, Alessandra Gorgulho, and Antonio De Salles Chapter 31: Nanomedicine in Demyelinating Disease: Application to Diagnosis and Therapy in Multiple Sclerosis Emily C. Leibovitch and Steven Jacobson Chapter 32: Applications of Nanotechnology in Degenerative Disorders of the Brain Ayaz M. Khawaja and John D. Heiss Chapter 33: Brain–Machine Interface and Rehabilitation Martin Pham, Alexander Taghva, and Ali R. Rezai Chapter 34: Nanobioelectronics for Noninvasive Neuronal Therapy Evangelia Hondroulis, Jairo Nelson, and Chen-Zhong Li Chapter 35: In Vitro and In Vivo Techniques to Assess Neurotoxicity of Nanoparticles Thomas Birngruber, Eleonore Fröhlich, Frank Sinner, and Thomas Pieber Chapter 36: Nanorobotics for Neurosurgery Robbin Miranda, Gill Pratt, and Geoffrey S. F. Ling Chapter 37: Imaging and Tracking Therapeutic Cells with Nanoparticles Gang Niu and Joseph A. Frank Chapter 38: Micro- and Nanotechnology in Nerve Repair Ali C. Ravanpay and Michel Kliot Chapter 39: Nanotechnology: Applications to Pediatric Neurosurgery Giancarlo Suffredini and Robert F. Keating Chapter 40: Food and Drug Administration Regulatory Framework for Nanodrugs and Nanodevices and the Combination Nanodrug Vicky Yamamoto, Giancarlo Suffredini, John D. Heiss, David Mishelevich, Grant Palmer, Warren Grundfest, and Babak Kateb Chapter 41: Nanoneuroscience and Nanoneurosurgery: A Key Component of President Obama’s Brain Mapping Initiative Babak Kateb, Vicky Yamamoto, Peter Basser, Michael Roy, Lucien Levy, Jian Tajbakhsh, Gary Steinberg, Allyson Rosen, Keith L. Black, Charlie Teo, Kuldip Sidhu, Mitchel Berger, and Warren Grundfest