Kidney

Bridging the gap between advances in basic biology and chemistry and technological applications in the field of toxicity assessments, this book describes major areas of progress in the laboratory and clinic. In the first section, aspects of cellular organelles are discussed. The second section covers the basic principles and applications of modern toxicological tools such as transcriptomic, proteomic, and metabolomic approaches. In the third section, the recent developments on molecular modeling and systems biology are described with an eye on the future establishment of virtual cell technology. Finally, the book discusses clinical implications of acute and chronic renal toxicity. Features Discusses the increasing quantities of toxicants in the environment and how they affect human organs Covers toxicity caused in kidney as a major health issue Studies this issue with the aid of modern medical techniques such as microimaging, stem cell biology, proteomics, small RNAs etc. Table of Contents Section I Cellular Organelle-based Renal Toxicity Section II Transcriptomic Approaches Proteomic Approaches Metabolomic Approaches Section III Molecular Modeling – Molecular Design Systems Biological Approaches Virtual Cell Section IV Clinical Implication of Renal Toxicology Molecular Pathology of Renal Fibrosis Section V Classification of Nephrotoxicants