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Content
Previous books on this subject have largely been academically oriented and not intended to guide the practicing developmental or reproductive toxicologist. Useful and informative, this book blends the theoretical foundation with insights gained from hands-on experience. It includes tables of comparative developmental milestones - both pre- and postnatal, glossaries of descriptive terms used in developmental toxicity evaluation, and both US and international regulatory guidelines. Bridging the gap between theory and application, this is a handy single-source of essential information to use in planning, conducting, and interpreting studies. Table of Contents PRINCIPLES AND MECHANISMS Principles of Developmental Toxicology Revisited, R.D. Hood Experimental Approaches to Evaluate Mechanisms of Developmental Toxicity, E.M. Faustman, J.M. Gohlke, R.A. Ponce, T.A. Lewandowski, M.R. Seeley, S.G. Whittaker, and W.C. Griffith Pathogenesis of Abnormal Development, L.B. Fawcett and R.L. Brent Maternally-Mediated Effects on Development, R.D. Hood and D.B. Miller Paternally-Mediated Effects on Development, B.F. Hales and B. Robaire Comparative Features of Vertebrate Embryology, J.M. DeSesso HAZARD AND RISK ASSESSMENT AND REGULATORY GUIDANCE Developmental Toxicity Testing - Methodology, R.W. Tyl and M.C. Marr Nonclinical Juvenile Toxicity Testing, M.J. Beck, E.L. Padgett, C.J. Bowman, D.T. Wilson, L.E. Kaufman, B.J. Varsho, D.G. Stump, M.D. Nemec, and J.F. Holson Significance, Reliability, and Interpretation of Developmental and Reproductive Toxicity Study Findings, J. Holson, M.D. Nemec, D.G. Stump, L.E. Kaufman, P. Lindström, and B.J. Varsho Testing for Reproductive Toxicity, R.M. Parker The U.S. EPA Endocrine Disruptor Screening Program: In Vitro and In Vivo Mammalian Tier I Screening Assays, S.C. Laws, T.E. Stoker, J.M. Goldman, V. Wilson, L.E. Gray, Jr., and R.L. Cooper Role of Xenobiotic Metabolism in Developmental and Reproductive Toxicity, A.P. Kulkarni Use of Toxicokinetics in Developmental and Reproductive Toxicology, P.J. Wier Cellular, Biochemical, and Molecular Techniques in Developmental Toxicology, B.D. Abbott, M.B. Rosen, and G. Held Functional Genomics and Proteomics in Developmental and Reproductive Toxicology, O. Spiegelstein, R.M. Cabrera, and R.H. Finnell In Vitro Methods for the Study of Mechanisms of Developmental Toxicology, C. Harris and J.M. Hansen Statistical Analysis for Developmental and Reproductive Toxicologists, J.J. Chen Quality Concerns for Developmental and Reproductive Toxicologists, K.D. Barrowclough and K.L. Reed Perspectives on the Developmental and Reproductive Toxicity Guidelines, M.S. Christian, A.M. Hoberman, and E.M. Lewis Human Studies - Epidemiologic Techniques in Developmental and Reproductive Toxicology, B. Källén Developmental and Reproductive Toxicity Risk Assessment for Environmental Agents, C.A. Kimmel, G.L. Kimmel, and S.Y. Euling Principles of Risk Assessment-FDA Perspective, T.F.X. Collins, R.L. Sprando, M.E. Shackelford, M.F. Gruber, and D.E. Morse APPENDICES A. Terminology of Anatomical Defects B. Books Related to Developmental and Reproductive Toxicology C. Postnatal Developmental Milestones
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