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About one third of women diagnosed with breast cancer will develop metastatic disease and subsequently die from their advanced breast cancer. Recent developments with novel systemic drugs, palliative surgical techniques and diagnostic imaging have given hope for the treatment of patients whose breast cancer has spread beyond its primary tumour. Written by a team from leading cancer centres in Europe, including the UK's Royal Marsden Hospital, the Handbook of Metastatic Breast Cancer, Second Edition provides advanced scientific information and guidance on clinical problems associated with metastatic breast cancer. Highlights of the Second Edition include: * New chapters on specialist treatment options, gene expression signatures, biomarkers, and specialist support services for patients and their families * Significant updates to chapters discussing systemic treatments for breast cancer, including endocrine therapy, chemotherapy, targeted therapies, and bisphosphonates * Up-to-date information on diagnostic imaging and tumour assessment, including positron emission tomography and computed tomography * Up-to-date information on local treatment options for neurological, thoracic, orthopaedic, and hepatic complications This handbook will be a practical and comprehensive resource for medical and clinical oncologists, breast surgeons and radiologists, as well as neurosurgeons, clinical scientists, orthopaedic and thoracic surgeons. Contents 1. Introduction Stephen RD Johnston; Charles Swanton 2. The prognostic and predictive value of gene expression signatures in breast cancer Hatem A. Azim, Jr., Debora Fumagalli, Christos Sotiriou Section I – Systemic Treatments 3. Targeting ER positive metastatic breast cancer Stephen RD Johnston 4. Targeting HER2+ and Trastuzumab Resistant metastatic breast cancer Javier Cortes 5. Targeting Triple Negative Sporadic and hereditary BRCA related metastatic Breast Cancer Sarah Barton; Nick Turner 6. Chemotherapy and metastatic breast cancer Charles Swanton 7. Bisphosphonates and their role in metastatic breast cancer David A Cameron 8. Targeting Angiogenesis in Metastatic Breast Cancer David Miles Section II – Imaging and Response Assessment 9. Imaging in the management of metastatic breast cancer David MacVicar 10. Positron emission tomography/computed tomography in metastatic breast cancer Bhupinder Sharma; Asim Afaq 11. Novel biomarker approaches for improving therapeutic strategies in metastatic breast cancer Roberta Ferraldeschi; Gerhardt Attard Section III – Local Treatment Options 12. Palliative radiotherapy in the management of metastatic breast cancer Anthony Chalmers; Richard Simcock 13. Management of neurological complications in metastatic breast cancer Adrian Casey; Syed MR Kabir 14. Thoracic complications George Ladas 15. Orthopaedic complications Kuldeep K Stohr; Stuart C Evans 16. Thermal ablation of hepatic metastases Andy Adam 17. Palliative Care and Metastatic Breast Cancer Jayne Wood; Anna-Marie Stevens 18. Specialist Support Services and Information Needs for Patients Melissa Warren; Diane Mackie
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