Handbook of Dystonia

As many as 250,000 people in the US have dystonia, making it the third most common movement disorder following essential tremor and Parkinson's disease. This authoritative reader-friendly resource provides a wide-ranging overview of the latest research and developments regarding the pathogenesis, evaluation, and management of the disease. Offering detailed coverage of every available treatment option for dystonia, including four categorized sections on medical management, botulinum toxin injections, phenol or neurolytic therapy, and surgical intervention. This source summarizes what is known about the disorder and dramatically improves the recognition and understanding of this debilitating disease.The most important update to the second edition is the addition of four new chapters dedicated to the discussion of individual botulinum toxins recently approved to treat dystonia: Botox, Myobloc, Disport, and Xeomin. Other new chapters include a discussion of rapid-onset dytonia-parkinson’s, dystonic synptoms associated with parkinson’s disorders, the use of Transcranial Magnetic Stimulation (TMS) as a treatment option for dystonia, as well as a chapter dedicated to spasticity, its pathogenesis, evaluation, and treatment with toxins, other injectables or surgical therapies. * Filling a gap in the literature, this reference: * Reviews the genetic factors of dystonia, as well as supplies in-depth coverage of the neuroanatomy, neurophysiology, and neuropathology of the disease * Reviews secondary causes of dystonia including drug-induced and psychogenic presentations * Devotes a chapter to non-motor symptoms relating to movement disorders * Contains three chapters focusing on botulinum toxin in the treatment of dystonic disorders * Analyzes surgical approaches for treatment including deep brain stimulation for various types of dystonia * Contains clinical descriptions of idiopathic and task-specific dystonias About the Author Mark A. Stacy, Duke University Medical Center, North Carolina, USA. Dr Stacy, now a Professor of Neurology at Duke University, has attracted a team of internationally-recognised movement disorder specialists to write the first edition of the book. These experts have returned to update their chapters, and new treatment specialists have been recruited to write the new botulinum toxin chapters. Table of Contents SECTION I: EPIDEMIOLOGY AND PATHOGENESIS 1. Introduction to Dystonia Joohi Shahed; Joseph Jankovic 2. Epidemiology Dystonia Giovanni Defazio 3. Genetic Evaluation in Hereditary Dystonia Christine Klein; Laurie J. Ozelius 4. Functional Anatomy of the Basal Ganglia Jonathan W. Mink 5. Physiology of Primary Dystonia Holly A. Shill; Mark Hallett 6. Pathology of the Dystonias Ruth H. Walker; Kevin StP. McNaught; Daniel Perl 7. Neuroimaging in Dystonia A. R. Troiano; A. J. Stoessl SECTION II: SIGNS AND SYMPTOMS 8. Primary Generalized Dystonia Johan Samanta 9. Cranial Dystonia Pankaj Satija; William G. Ondo 10. Cervical Dystonia Khashayar Dashtipour; Mark Lew 11. Limb Dystonia Barbara I. Karp 12. Spasmodic Dysphonia Tanya K. Meyer; Andrew Blitzer 13. Embouchure and Other Task-Specific Musician’s Dystonias Steven E. Lo; Steven J. Frucht 14. Sports-Related Task-Specific Dystonia: The Yips Charles H. Adler 15. Dopa-Responsive Dystonia Masaya Segawa; Yoshiko Nomura; Nobuyoshi Nishiyama 16. Rapid Onset Dystonia-Parkinson Allison Brashear 17. Secondary Dystonia Arif Dalvi; Kelly E. Lyons; Rajesh Pahwa 18. Dystonic Symptoms Associated with Parkinsonian Disorder Eduardo Tolosa 19. Drug-Induced Dystonia Francisco Cardoso 20. Psychogenic Dystonia Anette Schrag; Anthony E. Lang 21. Nonmotor Symptoms in Dystonia Stewart A. Factor; Daniel Huddleston; Felicia C. Goldstein; Lynn Marie Trott 22. Spasticity Volker Dietz SECTION III: TREATMENT OPTIONS 23. Medical Therapy for Dystonia Roongroj Bhidayasiri; Daniel Tarsy 24. Anatomic Principles for Botulinum Toxin Injection Richard L. Barbano 25. Botulinum Toxin: From Molecule to Clinic Nicole Calakos 26. Botulinum Toxins in the Treatment of Dystonia Mark A. Stacy; Patrick Hickey 27. Botox onabotulinumtoxinA David Charles; Chandler Gill 28. Myobloc rimabotulinumtoxinB Christina Sampaio 29. Dysport abobotulinumtoxinA Werner Poewe; Sascha Hering 30. Xeomin incobotulinumtoxinA Dirk Dressler 31. Peripheral neurolysis in the treatment if dystonia Alberto Esquenazi 32. Selective Denervation in Cervical Dystonia Carlos A. Arce 33. Repetitive transcranial Magnetic Stimulation in the Treatment for Dystonia Angelo Antonini; Francesca Morgante 34. Brain Surgery for Dystonia Camilla Kilbane; William J. Marks, Jr.