Adipose Tissue in Health and Disease

The study of adipose tissue is directly related to our understanding of obesity and clinically important diseases in developed countries, in particular diabetes and cardiovascular disease.    This unique handbook presents a comprehensive overview of adipose tissue in health and disease, covering all different aspects of the topic. It is an essential resource on a topic vital for fighting the worldwide obesity epidemic.  Key features: Discusses recent discoveries Covers a wide range of different diseases Describes conditions or pathological processes associated with diseases Addresses an extensive interdisciplinary target group Meets the major interest and investment in the topic from the pharmaceutical industry  The book describes in detail the adipose tissue development and morphology before moving on to metabolic functions of adipose tissue. The volume then focuses on the endocrine functions, the relationship between adipose tissue and disease, and closes with the comparative and evolutionary aspects of adipose tissue. CONTENTS ADIPOSE TISSUE DEVELOPMENT AND MORPHOLOGY Transcriptional Control of Adipogenesis and Fat Cell Gene Expression Development of Adipose Tissue The Cellular and Molecular Basis of Functional Differences Among Fat Depots Plasticity of The Adipose Organ Biology of Adipose Tissue Stem Cells METABOLIC FUNCTIONS OF ADIPOSE TISSUE Molecular Mechanisms of Adipocyte Lipolysis New Developments in the Lipolytic Processing of Triglyceride-rich Lipoproteins Intracellular Fatty Acid Transport, Activation And Trafficking Aquaporins and Adipose Tissue Signaling Pathways Controlling Lipolysis ENDOCRINE FUNCTIONS OF ADIPOSE TISSUE Leptin Secretion and Action Adiponectin Pref-1 and ADSF/resistin, Two Secreted Factors from Adipose Tissue: Role in Adipogenesis and Insulin Resistance Adipose Tissue and Blood Pressure Regulation Adipokines, Inflammation, and Obesity ADIPOSE TISSUE AND DISEASE Depot Specific Biology of Adipose Tissues: Links to Fat Distribution and Metabolic Risk Viral Induction of Obesity and Adipogenesis Adipose Tissue Cachexia Obesity and Diabetes: Lipotoxicity Obesity and Cancer Overview of Acquired and Genetic Lipodystrophies Mouse Models of Lipodystrophy Caloric Restriction Thiazolidinedione action? Adipose Tissue PPARg and other Drugs Affecting Adipose Tissue Early Life Programming of Adipogenesis and Adiposity COMPARATIVE AND EVOLUTIONARY ASPECTS OF ADIPOSE TISSUE Evolutionary Aspects of Obesity and Adipose Tissue Function