Neurotrauma

Neurotrauma: A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury aims to bring together the latest clinical practice and research in the filed of two forms of trauma to the central nervous system: namely traumatic brain injury (TBI) and spinal cord injury (SCI). Nationally, more 1.9 million Americans sustain a traumatic brain injury annually. In parallel, there are an estimate of 12,000 new cases of SCI in the United States annually. In addition, approximately 1.2 million people live with paralysis due to SCI. In recent years, dramatic advancements in the field have resulted in much improved outcomes for patients and higher standards of care. This volume details the latest research and clinical practice in the treatment of neurotrauma, in a comprehensive but easy-to-follow format. Neurotrauma is a valuable resource for any clinician involved in caring for TBI and SCI patients, clinical research professionals, researchers, medical and graduate students, and nurse specialists.

Contents

I SEVERE TRAUMATIC BRAIN INJURY
1 History, Overview and Human Anatomical Pathology of Traumatic Brain Injury
Kentaro Shimoda, Shoji Yokobori, and Ross Bullock
2 Severe TBI in Military - Medical and Surgical Interventions
Geoff Ling
3 Pediatric Severe Traumatic Brain Injury Management
Kendra Woods and Michael Bell
4 Treatment of Severe Traumatic Brain Injury in the Scandinavian Countries, with Special Emphasis on the Lund Concept
Magnus Olivecrona
5 Abusive Head Trauma
Rachel Berger
6 Traumatic Cerebral Vascular Injury
Ramon Diaz-Arrastia
7 Disorders of Consciousness: Common Findings in Brain Injury
Calixto Machado
II MILD TRAUMATIC BRAIN INJURY AND CONCUSSIONS
8 The TRACK-TBI Approach: Redefining Severity and Outcome Assessments
John Yue, Geoff Manley
9 Acute Assessment of Mild Traumatic Brain Injury
Linda Papa
10 Current Knowledge of Blast Traumatic Brain Injury Mechanisms
Elizabeth Fievisohn and Pamela VandeVord
11 Adult and Pediatric Mild and Moderate Head Injury Management in Scandinavian Countries
Johan Undén
12 Challenges in Neurotrauma Management in India and Rapidly Growing Developing Countries
VD Sinha, GK Prusty
13 Chronic TBI in Veterans and Service Members: Clinical Assessment, Interventions, and Differentiation from PTSD
Harvey Levin
14 Chemosensory Impairment after TBI
Nathan Zasler
15 Return to Play, School or Work after Concussion
Charles H. Tator
16 The Link Between Traumatic Brain Injury and Neurodegenerative Diseases
R. Rubenstein
III NEUROIMAGING AND BIOMARKER ASSESSMENTS IN TBI
17 Neuroimaging and Its Application in the Diagnosis for Early Prognostication of TBI
Lijun Ba
18 The Potential of Brain-Specific Blood Biomarkers for TBI Patient Management, Diagnosis and Clinical Research
Glushakova and Ronald L. Hayes
19 The Role of Inflammation in Traumatic Brain Injury
Cristina Morganti-Kossmann
20 Glutamate Receptor Peptides in Acute Neurotrauma
Svetlana Dambinova and Galina Izykenova
21 Serum Markers of Subclinical Brain Damage in Low Grade Chronic Concussion and Asymptomatic Cerebral Small Vessel Disease
Sergio González-García
22 MicroRNA Biomarkers in Traumatic Brain Injury
Manish Bhomia
IV TRANSLATIONAL ANIMAL STUDIES OF TBI
23 Translational Mild Traumatic Brain Injury Research: Bridging the Gap Between Models and Clinical Uncertainty
Eugene Park and Andrew Baker
24 Military-relevant Rodent Models of Blast-induced Traumatic Brain Injuries
Ibolja Cernak
25 Pediatric TBI Models: Lessons Learned
Ramesh Raghupathi
26 Proteomics-based Strategies to Define Brain Tissue Biomarkers of Closed Head, Mild Traumatic Brain Injury in Translational Rodent Models
Angela Boutte and D. Shear
V CURRENT AND FUTURE TREATMENTS OF TBI
27 Neuroprotection in TBI
Dafin Muresanu
28 Bioengineering in Brain Trauma Research
Michelle LaPlaca
29 Neuroregenerative Medicine in TBI
Jinhui Chen
30 Stem Cell Studies in Traumatic Brain Injury
Sun Dong
VI SPINAL CORD INJURY
31 Spinal Cord Injury: Intensive Care Unit Neurointensive Care and Surgical Intervention
Michael Y. Wang
32 Animal Models of Spinal Cord Injury
Candace Floyd
33 Why Do We Not Have a Drug to Treat Acute Spinal Cord Injury?
James Geddes
34 Recent Development of Regenerative Strategies to Treat Spinal Cord Injuries
Riyi Shi
35 Stem Cell Therapy for Spinal Cord Injury
Ping Wu
VII COMMON THEMES BEETWEEN TRAUMATIC BRAIN AND SPINAL CORD INJURY
36 Therapeutic Hypothermia and Targeted Temperature Management in the Treatment of Traumatic Brain and Spinal Cord Injury
Dalton Dietrich
37 Autoimmunity Responses in Traumatic Brain Injury and Spinal Cord Injury
Zhihui Yang and F. Kobeissy, K. Wang

Dr. Kevin Wang is the Director of the Program for Neurotrauma, Neuroproteomics & Biomarkers Research and Associate Professor of Emergency Medicine at the University of Florida in Gainesville, Florida, USA. He is also Health Research Neuroscientist and Merit Award Principal Investigator at the Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center (Gainesville, FL). Dr. Wang is a neurotrauma researcher since the late 1990's. He has served as President and Council Member of the National Neurotrauma society, Board Member, Board of Governors of the International Brain Injury Association and Presidium Member of the Academy for Multidisciplinary Neurotraumatology. His research focus is translational research for traumatic brain injury, spinal cord injury, post-traumatic epilepsy, and chronic traumatic encephalopathy. Two acute TBI blood-based protein biomarkers he co-discovered at University of Florida have now been clinically validated. In 2018, these two TBI biomarkersreceived FDA approval as the first-in class in vitro diagnostic tests for detecting cranial CT abnormality in TB patients.